When I changed form VB5 to VB6, the biggest difference I noticed, was ADO.
It was possible to use ADO with VB5, however VB6 was 'aimed at ADO'
====> Before I get flamed from all directions <=========
I concede for the experiienced programmers it makes little difference, as they could use either version of VB with ADO.
However for the less experienced (I was once), the fact that VB6's bound controls were intended to bind to ADO, would make a big difference.

I wouldn't use a bound control now, if my life depended on it. So all those who are of the same ilk, don't flame me.