Set the exPictureBox1-4 SizeMode to Zoom (in the designer) as passel told you, then add a larger standard PictureBox set Name to largerPictureBox and set SizeMode to Zoom.
Then...

Code:
Private Sub exPictureBoxs_Click(ByVal sender As Object, ByVal e As System.EventArgs) Handles exPictureBox1.Click, exPictureBox2.Click, exPictureBox3.Click, exPictureBox4.Click
    largerPictureBox.Image = DirectCast(sender, exPictureBox).Image
End Sub