Actually I just figured it out and I was making it harder then it even had to be.

Code:
Private Sub Button3_Click(sender As Object, e As EventArgs) Handles Button3.Click 'Open Simulator
        If ComboBox2.Text = "Office Jet Pro 8600" Then System.Diagnostics.Process.Start("E:\Emulator Tool Project\Printer Sim\8600\8600 display.png")
        If ComboBox2.Text = "Emulator 1" Then System.Diagnostics.Process.Start("E:\Emulator Tool Project\Blackberry Sim\9000att\fledge.exe")
        If ComboBox2.Text = "Emulator 2" Then System.Diagnostics.Process.Start("E:\Emulator Tool Project\Blackberry Sim\9780tmobile\fledge.exe")
    End Sub