Example, we want to read data from sheet1, column A is first name, column B is last name, column C is age. The Excel file (change the name to your file name) in this example is in the same folder as the executable, if diffrerent you would alter the DataSource property in the Builder variable.

VS2010 code, Option Strict On, Option Infer On
Requires 1 ComboBox, 2 Labels

Code:
Imports System.Data.OleDb
Public Class Form1
    Private Sub Form1_Load(sender As Object, e As EventArgs) Handles MyBase.Load

        Dim Builder As New OleDbConnectionStringBuilder With
            {
                .Provider = "Microsoft.ACE.OLEDB.12.0",
                .DataSource = IO.Path.Combine(Application.StartupPath, "File1.xlsx")
            }

        ' Note HRD=No indicates the first row of the sheet is not data
        Builder.Add("Extended Properties", "Excel 12.0; HDR=No;")

        Dim SheetName As String = "Sheet1"
        Dim dt As New DataTable

        Using cn As New OleDbConnection With
            {
                .ConnectionString = Builder.ConnectionString
            }
            cn.Open()

            Dim cmd As OleDbCommand = New OleDbCommand(
                <Text>
                    SELECT 
                        F1 As FirstName, 
                        F2 As LastName, 
                        F3 As Age  
                    FROM [<%= SheetName %>$]
                </Text>.Value,
                cn
            )

            dt.Load(cmd.ExecuteReader)
            dt.DefaultView.Sort = "LastName asc"
        End Using

        ComboBox1.DisplayMember = "LastName"
        ComboBox1.DataSource = dt

        Label1.DataBindings.Add("Text", dt, "FirstName")
        Label2.DataBindings.Add("Text", dt, "Age")

    End Sub
End Class