How can I find the 32 bit number of a color?

[Edgemeal]

1. Use the Screen class to get the size of the desktop on the primary screen.

Couldn't you just get the pixel under the mouse pointer, maybe something like...

Private Sub Timer1_Tick(sender As System.Object, e As System.EventArgs) Handles Timer1.Tick
    Using bmp As New Bitmap(1, 1)
        Using g As Graphics = Graphics.FromImage(bmp)
            g.CopyFromScreen(MousePosition, Point.Empty, bmp.Size)
            Dim c As Color = bmp.GetPixel(0, 0)
            Debug.WriteLine(c)
        End Using
    End Using
End Sub