I am assuming you have two tables where the data for both the combo boxes comes from. So you have a table tblMake which tracks the vehicle make, and another table tblModel which tracks the model of the vehicle against each make. tblMake would probably have a primary key, let's call it MakeID. Similarly tblModel could have a primary key, ModelID. Most importantly, tblModel must have a field MakeID which contains the appropriate MakeIDs to link the two records. A sample of data would look something like this:

Code:
tblMake
MakeID  MakeName
01         Ford
02         Toyota

tblModel
ModelID  MakeID  ModelName
01         01         Focus
02         01         Taurus
03         01         Fiesta
04         02         Camry
05         03         Corolla
The simplest you could do is
1. Load up the first combo box with data from the first table, tblMake.
2. Handle the SelectedIndexChanged event of the combo to retrieve the make the user has selected
3. Use the index above to load up the second combo box with relevant data from the second table, tblModel.

Steps 2 and 3 would go into the SelectedIndexChanged event handler.

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