Thanks for the info on that. I added the IF and also created a test form, but I am just getting strange results, so I don't know where I am going wrong with this.

Code:
Public Class Form1

    Private allowTLPmove As Boolean = False
    Private newTLPpoint As New Point

    Private Sub TableLayoutPanel1_MouseDown(ByVal sender As Object, ByVal e As System.Windows.Forms.MouseEventArgs) Handles TableLayoutPanel1.MouseDown, TableLayoutPanel2.MouseDown, TableLayoutPanel3.MouseDown
        allowTLPmove = True
        newTLPpoint = New Point(e.X, e.Y)
        Me.Cursor = Cursors.SizeAll
    End Sub

    Private Sub TableLayoutPanel1_MouseMove(ByVal sender As Object, ByVal e As System.Windows.Forms.MouseEventArgs) Handles TableLayoutPanel1.MouseMove
        If allowTLPmove = True Then
            TableLayoutPanel1.Location = New Point(TableLayoutPanel1.Location.X + e.X - newTLPpoint.X, TableLayoutPanel1.Location.Y + e.Y - newTLPpoint.Y)
        End If
    End Sub

    Private Sub TableLayoutPanel2_MouseMove(ByVal sender As Object, ByVal e As System.Windows.Forms.MouseEventArgs) Handles TableLayoutPanel2.MouseMove
        If allowTLPmove = True Then
            TableLayoutPanel2.Location = New Point(TableLayoutPanel2.Location.X + e.X - newTLPpoint.X, TableLayoutPanel2.Location.Y + e.Y - newTLPpoint.Y)
        End If
    End Sub
    Private Sub TableLayoutPanel1_MouseUp(ByVal sender As Object, ByVal e As System.Windows.Forms.MouseEventArgs) Handles TableLayoutPanel1.MouseUp, TableLayoutPanel2.MouseUp, TableLayoutPanel3.MouseUp

        If allowTLPmove Then
            allowTLPmove = False
            Me.Cursor = Cursors.Default
            My.Settings.TblPanel1 = TableLayoutPanel1.Location
            My.Settings.TblPanel2 = TableLayoutPanel2.Location
            My.Settings.TblPanel3 = TableLayoutPanel3.Location
            My.Settings.Save()
        End If
    End Sub

    Private Sub Form1_Load(sender As Object, e As EventArgs) Handles MyBase.Load

        TableLayoutPanel1.Location = My.Settings.TblPanel1
        TableLayoutPanel2.Location = My.Settings.TblPanel2
        TableLayoutPanel3.Location = My.Settings.TblPanel3

    End Sub
End Class