This depends on even more things factoring in (everything the others already said not withstanding)

Let's say you decide to "buy" a Service (Cloud, dedicated provider, whatever).

Usually, connection to "somewhere" via Internet (and it doesn't matter if it's a DB-Server, FTP-Server, whatever),
the Download-Speed is way higher than upload-speed (e.g. my parents have a DL-Speed 4-5 times the UL-speed).

So, a DB-Server within a LAN is not "realistically" comparable to a DB-Server "bought" from a Service in terms of "speed"-performance

I'm working in a company, which has a company-only WAN (basically a LAN via MPLS) with 12 subsidiaries world-wide, with some 400-500 users (many with multiple sessions and/or Software-Clients),
resulting in some 1500-2000 parallel connections daily (!!) to our centralized DB-Server, with no noticable lag in the connection.
No Proxy for load-balancing, no nothing. All sessions directly to the DB-Server.

Something to think about