Maybe because I'm binding two different sets of data to the grid?

1. I manually added columns in the graphical display and they are unbound.
2. I bind data to the grid which adds columns to the right.
3. I bind data to the 'POItems' DataGridViewComboBox column based on user selection on the form itself.
4. User makes a selection from the DataGridViewComboBox that populates the other columns in the row. <-- clicking out of this cell reverts back to the original or random selection on the ComboBox.

Is it not legal to have two different sets of data on the grid? It's that what is freaking it out?