I've been coding an program for my friends on VB 2010 and I've published the program for them and the problem what im running into is that it shows an Microsoft .NET security warning witch stops every function of the program.
Not enough information, even with the screenshot.

I am assuming your making a web application since your publishing your app is that right? or is it a click-once install or something like that?

Where are you publishing it? on your friends PC? or into a server?