You can do all those things using Graphics commands in the Paint Event handler of the PictureBox. There's a lot to learn about using Graphics commands, so if you haven't done it before it would be worth looking for a tutorial (I think DDay has one in this forum's CodeBank). To give you an idea of what the code might look like:
Code:
   Dim boa As Image = Image.FromFile(filename1)
   Dim cat As Image = Image.FromFile(filename2)
   Dim dog As Image = Image.FromFile(filename3)

   Private Sub PictureBox1_Paint(sender As Object, e As PaintEventArgs) Handles PictureBox1.Paint
      Dim g As Graphics = e.Graphics
      'draw boa at position (15, 20)
      g.DrawImage(boa, 15, 20)
      'draw cat at position 50,60 at twice actual size:
      g.DrawImage(cat, 50, 60, cat.Width * 2, cat.Height * 2)
      'draw dog rotated 37 degrees around point 100,100:
      g.TranslateTransform(100, 100)
      g.RotateTransform(37)
      g.TranslateTransform(-100, -100)
      g.DrawImage(dog, 100 - dog.Width \ 2, 100 - dog.Width \ 2)
   End Sub
BB