Well, i found some things about RegisterHotkey API, but I still have an issue to toggle off the hotkey...

Code:
Public Class Form1

#Region "REGISTER HOTKEYS"


Public Const WM_HOTKEY As Integer = &H312

<DllImport("User32.dll")> _
Public Shared Function RegisterHotKey(ByVal hwnd As IntPtr, _
                        ByVal id As Integer, ByVal fsModifiers As Integer, _
                        ByVal vk As Integer) As Integer
End Function

<DllImport("User32.dll")> _
 Public Shared Function UnregisterHotKey(ByVal hwnd As IntPtr, _
                        ByVal id As Integer) As Integer
End Function
#End Region

Private Sub Form1_Load(ByVal sender As System.Object, ByVal e As System.EventArgs) Handles MyBase.Load

RegisterHotKey(Me.Handle, 1, 0, Keys.NumPad8) 'REGISTER NUMPAD8

End Sub


Protected Overrides Sub WndProc(ByRef m As System.Windows.Forms.Message)

If m.Msg = WM_HOTKEY Then
            Dim id As IntPtr = m.WParam
            Select Case (id.ToString)
                Case "1"
                    RegisterHotKey(Me.Handle, 1, 0, Keys.NumPad8)
                    checkbox1.checked=true
            End Select
        End If
        MyBase.WndProc(m)
End Sub

End Class
So, where do I place this flag "CheckBox1.Checked = Not CheckBox1.Checked" to toggle on/off the checkbox?