There are pros and cons with both C# and VB.NET when compared to each other, although the differences are not huge. One thing to consider when coming from VB6 is how your existing knowledge will affect your learning of the new language. Many believe that VB6 knowledge is actually a hindrance to learning VB.NET because they are similar enough that you expect VB.NET to work the same way as VB6 does, but it doesn't. As is the case with sport and many other things, sometimes it's easier to learn something different than something similar to what you already know. In the end though you can pretty much do whatever with either language.