I don't really see how that's possible. I just created a new WinForms app and added a ComboBox to the form. I then changed the form's code file to this:
C# Code:
  1. using System;
  2. using System.Collections.Generic;
  3. using System.ComponentModel;
  4. using System.Data;
  5. using System.Drawing;
  6. using System.Text;
  7. using System.Windows.Forms;
  8.  
  9. namespace WindowsApplication1
  10. {
  11.     public partial class Form1 : Form
  12.     {
  13.         public Form1()
  14.         {
  15.             InitializeComponent();
  16.         }
  17.  
  18.         private void Form1_Load(object sender, EventArgs e)
  19.         {
  20.             List<Order> orders = new List<Order>();
  21.  
  22.             orders.Add(new Order(1, "alpha"));
  23.             orders.Add(new Order(2, "november"));
  24.             orders.Add(new Order(3, "tango"));
  25.             orders.Add(new Order(4, "tangle"));
  26.  
  27.             this.bindingSource1.DataSource = orders;
  28.             this.comboBox1.DataSource = this.bindingSource1;
  29.         }
  30.  
  31.         private void comboBox1_SelectedIndexChanged(object sender, EventArgs e)
  32.         {
  33.             Console.WriteLine((this.bindingSource1.Current as Order).Name);
  34.         }
  35.     }
  36.  
  37.     public class Order
  38.     {
  39.         private int _id;
  40.         private string _name;
  41.  
  42.         public int ID
  43.         {
  44.             get { return _id; }
  45.             set { _id = value; }
  46.         }
  47.  
  48.         public string Name
  49.         {
  50.             get { return _name; }
  51.             set { _name = value; }
  52.         }
  53.  
  54.         public Order(int id, string name)
  55.         {
  56.             this._id = id;
  57.             this._name = name;
  58.         }
  59.     }
  60. }
When I ran the project the Output window showed "alpha" as expected as the first item was selected. I then typed "t" and "a" and, as expected, there was no new output because entering characters into the box doesn't raise the SelectedIndexChanged event.

I suggest that you place a breakpoint on the first line of the event handler and then when it's hit take a look at the Call Stack window to see where it has come from. I just don't see how it could be caused merely by entering a letter in the box.