10% probability of dying

[jmcilhinney]

I would go along these lines. A 5x5 grid sounds like a good use of a TableLyoutPanel. You'd place your 25 Labels in the cells of the table and then do something like this:

Dim myRandom As New Random
 
For Each lbl As Label in myTableLayoutPanel.Controls
    If myRandom.Next(0, 10) = 0 Then
        'Kill the Label.
        lbl.Dispose()
        myTableLayoutPanel.Controls.Remove(lbl)
    End If
Next lbl