Your best bet would be a Sub Main

Example:
VB Code:
  1. Module Module1

  2.    Public Sub Main()

  3.       Dim frm as new Form1

  4.       If something = True Then

  5.           Application.Run(frm)

  6.       Else

  7.          Something else

  8.       End If

  9.    End Sub

  10. End Module