datagrid [RESOLVED]

[Slow_Learner]

Then you probably want the DataGrid.CurrentCellChanged event.
ms-help://MS.VSCC/MS.MSDNVS/cpref/html/frlrfsystemwindowsformsdatagridclasscurrentcellchangedtopic.htm

e.g.:
Private Sub DataGrid1_CurrentCellChanged(ByVal sender As Object, ByVal e As System.EventArgs) Handles DataGrid1.CurrentCellChanged

Oh and as to:

        Dim sFirstCell As String = e.Item.Cells(0).Text 
        Dim sSecondCell As String = e.Item.Cells(1).Text

based on:
ms-help://MS.VSCC/MS.MSDNVS/cpref/html/frlrfsystemwindowsformsdatagridclassitemtopic.htm

it would end up being (at least the way I would do it):

        Dim sFirstCell As String = DataGrid1(DataGrid1.CurrentRowIndex, 0)   'cell 0
        Dim sFirstCell As String = DataGrid1(DataGrid1.CurrentRowIndex, 1)   'cell 1