Yes u can:

VB Code:
  1. Public Declare Function SystemParametersInfo Lib _
  2. "user32" Alias "SystemParametersInfoA" (ByVal uAction _
  3. As Long, ByVal uParam As Long, ByVal lpvParam As Any, _
  4. ByVal fuWinIni As Long) As Long
  5.  
  6. Sub DisableKeys(bDisabled As Boolean)
  7.     Dim X As Long
  8.     X = SystemParametersInfo(97, bDisabled, CStr(1), 0)
  9. End Sub
  10.  
  11. 'To disable Ctrl-Alt-Del etc use this:
  12. DisableKeys (True)
  13. 'Use this in your Form_Unload to re-enable the keys:
  14. DisableKeys(False)