Saving a picture without manually choosing the location?

[Karl.Green]

I can do the file name, I am unsure how to add the location in?

I have

quicksave.FileName = "screenshot" & intCount + 1
 
        PictureBox1.Image.Save(quicksave.FileName, System.Drawing.Imaging.ImageFormat.Jpeg)

and I want it to save to "C:\Users\Karl\Desktop\Screenshot"?