I'm having a weird occurrence with Internet Explorer 6

I am trying to test out the differences of some sites with different browsers.
However, whenever I paste a URL in the IE address bar and click GO (or press return) IE goes to my homepage and the URL opens in Firefox!

I've done the usual malware checks and nothing obvious came up.

Maybe its a feature of some legitimate program that I forgot about?

Its quite difficult to search for as well as the keywords are too common to narrow the results down!

Anyone seen anything like this before?