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Thread: Doubling time Formula

  1. #1

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    Question Doubling time Formula

    Can Anyone help me with this problem, i need a formula to work out how long it takes Bacteria to multiply !

    Ok heres the information i start out with:

    Initial number of bacteria
    End number of bacteria
    Time elapsed

    assumptions:
    Bacteria grow by division into two, therefore each round of growth the number of bacteria double.
    There are no deaths and the division is always perfect

    So i want to know how long it takes for each division to complete.

    eg start with 1 bacteria, end with 4 and total time is 4 hours, then the doubling time would be 2hours - 2 divisions / 4 hours
    intuitive, easy ! but whats the formula ?

    FYI the actual numbers involved would typically be

    start 0.34
    end 3.2x10^8
    time 144 hours

    Help !
    TY

  2. #2
    vbuggy krtxmrtz's Avatar
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    The time it takes for a division cycle is the total time over the number of divisions. The latter are calculated in this fashion:

    Let i be the i-eth division step and N(i) the number of bacteria just before that step. Then:

    N(2) = 2*N(1) = 21*N(1)
    N(3) = 2*N(2)=2*2*N(1) = 22*N(1)
    N(4) = 2*N(3) = 2*2*N(2) = 2*2*2*N(1) = 23*N(1)
    ...
    N(k) = 2k*N(1)

    so after k steps you end up with N(k) bacteria. Then, inverting the formula,

    k = log[N(k)/N(1)] / log(2)

    and the time per division step is therefore:

    t = T / k

    where T is the given total time.

    Applied to your example:

    k = log(3.2*10^8/0.34)/log(2) = 29.810
    t = 144 h / 8.974 = 4.831 hours

  3. #3
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    Are you really starting with 34/100 of a bacterium?

    From what you describe, it seems that you should start by dividing the final number of bacterai by the starting number. This should be a power of two, say 210 for example. That would indicate ten divisions. Divide into the time.
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