I used 2 resources from NuGet Dropbox.api and System.IO.compression.ZipFile

The way I have my program set up is to directly publish to my dropbox api folder but, you could migrate the updates you want manually as well.
You can set up a DropBox api account at: https://www.dropbox.com/developers

Note: This does require the program to be initially installed from the downloads folder due to the quirks of ClickOnce, you can always change the path to your liking as well.

I don't know if anyone could use this here but I figured id put it out there as a relatively easy way to set up updates for ClickOnce software.

Imports Dropbox.Api

Public Class Form1
Public Version as String
Public Update as Boolean

'Gets the Currents version of your program and checks it against the latest version the the dropbox folder
Private Async Function CheckVersion() As Task
        Using drp = New DropboxClient("DropBoxToken")
            Dim Ver = My.Application.Info.AssemblyName +"_" + Version.Replace(".", "_")

                Dim VersionsonDB = Await drp.Files.ListFolderAsync("/Application Files")

                Latest = (VersionsonDB .Entries(VersionsonDB .Entries.Count - 1).Name)
                If Latest = Ver Then
                    If MsgBox("Update Found Would you like to Download it?", MsgBoxStyle.YesNo, My.Application.Info.AssemblyName +" Update") = MsgBoxResult.Yes Then
                        Update = True
                        Update = False

                    End If
                End If

            Catch e As ApiException(Of Files.GetMetadataError)
            End Try
        End Using
    End Function

'Downloads the needed files to update your program
Private Async Function downloadUpdate() As Task
        Dim path = Environment.GetFolderPath(Environment.SpecialFolder.UserProfile) & "\Downloads\"
        If System.IO.File.Exists(path + "setup.exe") Then
            System.IO.File.Delete(path + "setup.exe")
        End If
        If System.IO.File.Exists(path + My.Application.Info.AssemblyName + ".application") Then
            System.IO.File.Delete(path + My.Application.Info.AssemblyName + ".application")
        End If
        If System.IO.Directory.Exists(path + "Application Files") Then
            System.IO.Directory.Delete(path + "Application Files", True)
        End If
        Using drp = New DropboxClient("DropBoxToken")

            Using response = Await drp.Files.DownloadAsync("/setup.exe")
                System.IO.File.WriteAllBytes(path + "setup.exe", Await response.GetContentAsByteArrayAsync)
            End Using

            Using response = Await drp.Files.DownloadAsync("/"+My.Application.Info.AssemblyName + ".application")
                System.IO.File.WriteAllBytes(path + My.Application.Info.AssemblyName+ ".application", Await response.GetContentAsByteArrayAsync)
            End Using

            Using response = Await drp.Files.DownloadZipAsync("/Application Files/" + Latest)
                System.IO.Directory.CreateDirectory(path + "Application Files")
                System.IO.File.WriteAllBytes(path + "Application Files/Latest.zip", Await response.GetContentAsByteArrayAsync)
                System.IO.Compression.ZipFile.ExtractToDirectory(path + "Application Files/Latest.zip", path + "Application Files/")
            End Using
        End Using
    End Function

Public Sub CheckForUpdate()
        Version = My.Application.Deployment.CurrentVersion
        Dim path = Environment.GetFolderPath(Environment.SpecialFolder.UserProfile) & "\Downloads\"
        Dim task1 = Task.Run(Function() CheckVersion())
        If Update Then
            task1 = Task.Run(Function() downloadUpdate())
            Process.Start(path + "setup.exe")
            Exit Sub
        End If
End Sub

End Class