EXE doesn't open on some computers

I am new to .NET but vba/vb6 developer for years. Developing at a company where I don't have admin rights to computers. I created a simple desktop app (really simple) and did a network clickonce deployment. It works fine on most computers... BUT - nothing on one computer (computer A). No message, no start menu, nothing. App has no dependencies other than .NET framework. If I just copy the exe onto the same computers, it works fine on all computers except computer A. Computer A has the correct framework installed. When I double click the exe it does nothing - no message, no error, not showing up in task manager, notta. I tried more than one application and it performs the same.

I assume it is something to do with the .NET configuration on the computer, but I really have no idea where to start.

Any suggestions?

Joel