Communication with usb

Please help us, how to communication vb with usb??:o:o:o:o

Welcome to the forums. :wave:

What USB device are you wanting to use?
What hardware are you wanting to interface?
What specifically are you trying to accomplish?

You simply haven't given nearly enough information to provide any kind of answer.

i want to communicate between visual basic and microcontroller 89c51 via usb port, when we press '1' at keyboard so one Led become ON at port1
when we press '2' at keyboard so two Led become ON at port1
so, what script for do that?
sorry, about bad english.