Rootkit Detection in VB - Is it Possible?

Is it possible for a VB6 program to detect rootkits such as hidden processes? If it is, is it possible to do it in user mode, not kernel mode? I've never seen a pure VB program that can run in kernel mode. Actually, I'm not really sure what kernel mode is but I'm pretty sure it involves creating a driver/.sys file and it allows more access than user mode.

This is more an application for something like C or C++