Possible to use predefined variables in column expression?

I have some variables that I would like to include in an expression statement for a column that is part of a datatable. Is this possible?

Please explain it properly or if possbile then by any example scenario.

So instead of defining an expression based on math using other column names, e.g.:

DataGridView.Columns("SumZ").Expression = "HZ + RZ"

I want to do something like:

Dim mean As Integer = 10
DataGridView.Columns("SumZ").Expression = "(HZ + RZ) / mean"

Does this make sense?