How can I set image pixel into picturebox?

Hi,
I'm wondering howto set an image pixel into a picturebox in vb.net. I used to do it using setpixel function where it needed picturebox.hdc as parameter. The question is now no more hdc in vb.net. I've tried looking ino GDI+, but stil not manage to figure it out in vb.net ..can someone outhere help me?

vb 6 code
SetPixel(Picture2.hdc, x1, y1, pCol1)

Thanx in advance..