Distributing applications to be run directly from CD

Im designing an application that needs to be run directly from CD ie. NOT INSTALLED. Normally I would put all the boot strap files
and necessary exe's, ocx's & dll's onto the CD in the root, but with this application (which uses a CSV file as a database) I get an error message when installing on a "clean machine"
Couldn't find installable ISAM..... etc.
I realise that certain files need to be registered.
Question: Can I do this programmatically ie. maybe in a form load proceedure? or does the application need to be installed (using the Package & Deployment wizard)?

VB EXEs *MUST* have the runtimes installed on the local system in order to run. They will not work without it. The Package And Deployment wizard does this for you, but you could use another installer - INNO, Visual Studio Installer etc.

The VB runtime files have to be installed for your app to even start. If you install those at the minimum, you may be able to register the activex controls on your cd at runtime. But you'll have to register them before any forms are loaded that use them or any other references are made. It might not work anyway. I've never tried it myself, but you can find out by installing the VB runtimes on a "clean" machine and then seeing what happens when you try to run your app.