Problems with .Net Update

I installed the .Net update yesterday from MS and now I'm having a problem with a web project.

I'm getting these 3 errors the 2nd time I run my project:

Quote:

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The file 'bin\sopon.net.pdb' cannot be copied to the run directory. The process cannot access the file because it is being used by another process.

Could not copy temporary files to the output directory.
The file 'bin\sopon.net.dll' cannot be copied to the run directory. The process cannot access the file because it is being used by another process.

The file 'bin\sopon.net.pdb' cannot be copied to the run directory. The process cannot access the file because it is being used by another process.

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I've tried bouncing my SQL Server, IIS Manager and VS. The only thing that works is restarting my computer and that, of course, isn't an option. There's 1.8 gigs of space left on my HD, the length of the path is 33 and I only have ASPX, a Config, CSS, and a vsdisco file.

Anyone have any clue what I should do?