I've only ever written a single jQuery app (I've been developing it for about 18 months now).

It's a single page - never leaves the page - all async access to web methods.

My single .Ready event looks like this. Would it benefit from any changes??

Code:
$(document).ready(function() {

    $("#acs-tabset").tabs({ show: function(event, ui) { resizeStuff() } }).data("lastpanel", "1");
    initializeTab();

    $("#acs-close-tracker").button({ text: false, icons: { primary: "ui-icon-triangle-1-s"} }).click(function() {
        $("#acs-work").removeClass("acs-work-full-size");
        $("#acs-tracker").toggle(0, trackerToggle);
        return false;
    });

    $("#acs-show-binder").button({ text: true, icons: { primary: "ui-icon-triangle-1-e"} }).attr('disabled', 'disabled').click(function() {
        //$("#acs-work").removeClass("acs-work-full-size");
        if ($("#acs-tracker").is(':hidden')) {
            $("#acs-work").removeClass("acs-work-full-size");
            $("#acs-tracker").toggle(0, trackerToggle);
        }
        $("#acs-binder-panel").toggle(0, binderToggle);
        return false;
    });

    $("#acs-logout").button({ text: true, icons: { primary: "ui-icon-power"} }).attr('disabled', 'disabled').click(function() {
        $("#acs-binder-info").html('Logging out...<img src="Images/ajax-loader-small.gif" />');
        closeAll();
        $("#acs-binder-info").html('');
        g_warning = false;
        return false;
    });

    $("#acs-show-reflectors").button({ text: false, icons: { primary: "ui-icon-gear"} }).click(function() {
        showReflectors();
        return false;
    });

    $("#acs-clear-spcache").button({ text: false, icons: { primary: "ui-icon-wrench"} }).click(function() {
        ctrlWebService("spcache", "clear", "", "");
        return false;
    });

    $('.acs-panel-btn-add').live('click', addClick);
    $('.acs-panel-btn-delete').live('click', deleteClick);
    $('.acs-panel-btn-edit').live('click', editClick);
    $('.acs-panel-btn-open').live('click', openClick);
    $('.acs-operator-button-event').live('click', operatorClick);
    $('.acs-panel-btn-clear').live('click', clearClick);
    $('.acs-panel-btn-sort').live('click', sortClick);
    $('.acs-panel-btn-reader').live('click', readerClick);
    $('.acs-panel-btn-next').live('click', nextClick);
    $('.acs-panel-btn-prev').live('click', prevClick);
    $('.acs-panel-btn-reader-next').live('click', nextReaderClick);
    $('.acs-panel-btn-reader-prev').live('click', prevReaderClick);
    $('.acs-panel-btn-close').live('click', closeClick);
    $('.acs-panel-btn-newwindow').live('click', newwindowClick);
    $('.acs-panel-btn-closetab').live('click', closetabClick);
    $('.acs-panel-btn-save').live('click', saveClick);
    $('.acs-panel-btn-undo').live('click', undoClick);
    $('.acs-panel-btn-popup').live('click', popupClick);
    $('.acs-panel-btn-refresh').live('click', refreshClick);
    $('.acs-panel-btn-print').live('click', printClick);
    $('.acs-panel-btn-run').live('click', runClick);
    $('.acs-reader-aggbtn').live('click', aggbtnClick);
    $('.acs-input-field').live('focusin', focusinField);
    $('.acs-input-field').live('change', changeField);
    $('.acs-input-setThisPay').live('change', setThisPay);
    $('.awc-prob').live('change', setThisPay);
    $('.acs-panel-btn-page').live('click', pageClick);
    $('.acs-grid-btn-reqapp').live('click', reqappClick);
    $('.acs-grid-btn-operator').live('click', gridOperatorClick);
    $('.acs-grid-chk-hdr').live('click', checkboxhdrClick);
    $('.slick-cell-checkboxsel').live('click', checkboxClick);
    $('.acs-sproc-button').live('click', sprocClick);
    $('.acs-saveadd-button').live('click', saveaddClick);
    $('.acs-saveclose-button').live('click', savecloseClick);
    $('.acs-savenext-button').live('click', savenextClick);

    $('.awc-prob').live('click', probClick);

    $('.acs-download').live('click', downloadClick);

    $('#acs-error').dialog({ autoOpen: false, modal: true, position: { my: "left top", at: "left center", of: "#acs-work"} });
    $('#acs-prompt').dialog({ autoOpen: false, modal: true, position: { my: "left top", at: "left center", of: "#acs-work"} });
    $('#acs-formula').dialog({ autoOpen: false, modal: true, position: { my: "left top", at: "left center", of: "#acs-work" }, minWidth: 970 });
    $('#dlgChartType').dialog({ autoOpen: false, modal: true, position: { my: "left top", at: "left center", of: "#acs-work"} });
    $('#dlgAddWhat').dialog({ autoOpen: false, modal: true, position: { my: "left top", at: "left center", of: "#acs-work"} });
    $('#dlgChoice').dialog({ autoOpen: false, modal: true, closeOnEscape: false, position: { my: "left top", at: "left center", of: "#acs-work"} });
    $('#dlgReloadGrid').dialog({ autoOpen: false, modal: true, position: { my: "left top", at: "left center", of: "#acs-work"} });

    var options = {};
    options.drop = dropOn;

    $('#acs-panel1').parent().droppable(options);

    $(window).resize(resizeStuff);
    resetWindowSize();

    $.extend($.ui.autocomplete, {
        escapeRegex: function(value) {
            return value.replace(/[-[\]{}()*+?.,\\^$|#\s]/g, "\\$&");
        },
        filter: function(array, term) {
            var matcher = new RegExp($.ui.autocomplete.escapeRegex(term), "i");
            var arraytoreturn = $.grep(array, function(value) {
                return matcher.test(value.label || value.value || value);
            });
            if (arraytoreturn.length > 200) {
                arraytoreturn = [{ label: "Please be more specific - " + arraytoreturn.length + " matching entries!", value: ""}];
            }
            return arraytoreturn;
        }
    });

    urlParams.id = urlParams.id || "";

    $("#acs-username,#acs-password").keyup(function(e) {
        loginKeyUp(e, this);
    });

    if (urlParams.id === "") {
        $('#dlgLogin').dialog({ title: 'Log in', modal: true, closeOnEscape: false, buttons: { 'Log in': function() { loginClick(this) } } });
    } else {
        $("#acs-login-error").html('<img src="Images/ajax-loader-small.gif" />');
        ctrlWebService("userid", urlParams.id, "", "");
    }

    window.onbeforeunload = function() {
        if (g_warning) {
            return 'You have made changes on this page that you have not yet confirmed.  If you navigate away from this page you will lose your unsaved changes';
        }
    }

});