I get the same type error when running an SSIS package set in Studio (file in use). It is always related to memory for me (2 Gig machine but 6 gig in use) I use the package to migrate a database (it is about 20 gig in size). The error occurs at different places in the process some times when I call 1 package (Migrate 3) other time a different 1 (migrate 5) I have 10 packages that get called from one starting package.