OK Stimbo, i'm ready for you to beat me up again.
This is what I have, during debugging it works just fine. But when I publish it and install it from CD-Rom i keep getting:
Unhandled exception, cannot find file c:\users\name\docs\openfiledialg.

Code:
Dim strList As String
        Dim mystreamreader As New StreamReader(OpenFileDialog1.FileName, True)

        OpenFileDialog1.InitialDirectory = "c:\temp\"
        OpenFileDialog1.Title = "Select a File"
        OpenFileDialog1.FileName = ""
        OpenFileDialog1.Filter = "Text Files (*.txt)|*.txt"
        OpenFileDialog1.FilterIndex = 1
        OpenFileDialog1.FileName = "myfile"

        If OpenFileDialog1.ShowDialog() <> Windows.Forms.DialogResult.Cancel Then
            lbxInput.Items.Clear()
            strList = mystreamreader.ReadLine()
            Do Until strList Is Nothing
                lbxInput.Items.Add(strList)
                strList = mystreamreader.ReadLine()
            Loop
            mystreamreader.Close()
            mystreamreader.Dispose()
            gbxRandom.Enabled = True
            gbxResults.Enabled = True

        End If